Actuating Scaffolds

Tissues are constantly subjected to external stimuli that can be mechanical, electrical or chemical. These stimuli are dynamic input signals that are transmitted to the cell nucleus and translated into responses affecting their survival, proliferation, migration, differentiation, and more. Thus, controlling the external signals that cells sense allows us to control their fate and, hence, the kind of tissue they produce.

At BioSmarTE we develop smart stimuli responsive scaffolds that can be actuated remotely after implantation. Very much like in the gym, these stimuli become the training routine of cells on their path to healing and regenerating a healthy and coherent tissue. Currently, we focus on the development of scaffolds that can be actuated with sonic, magnetic and electric signals.